Hair Loss Blog

Clin Ophthalmol. 2010 Apr 26;4:349-58.

Bimatoprost in the treatment of eyelash hypotrichosis.

Law SK.

edited for hai rloss treatment blog

Eyelashes hypotrichosis is a condition indicated by an inadequate amount of
eyelashes. Hypertrichosis of eyelashes, characterized by excessive eyelash
growth, is a regular phenomenon associated with ophthalmic prostaglandin and
prostamide analogs. Recently, the US Food and Drug Administration approved
Latisse((R)) (bimatoprost 0.03% solution), identical to the ophthalmic solution
for glaucoma treatment, for increasing eyelash length, thickness and darkness in
patients with hypotrichosis of the eyelashes. When prostaglandin and prostamide
analogs interact with the prostanoid receptors in the hair follicle, this most
likely stimulates the resting follicles (telogen phase) to growing follicles
(anagen phase). Prostaglandin and prostamide analogs may also prolong the anagen
phase of eyelashes, leading to an increase of eyelash length. Although
bimatoprost is effective in promoting increased growth of healthy eyelashes and
adnexal hairs, its effectiveness in patients with eyelash with hai rloss due to alopecia areata is debatable and its protective effect is not yet studied in patients with eyelash
loss secondary to radiation or chemotherapy. Bimatoprost is generally safe when
applied to the base of the eyelashes at the lid margin with minimum side effects.
However, other ocular or systemic side effects associated with ophthalmic
prostaglandin and prostamide analogs may occur when instilled on the surface of
the eye, and patients must be informed and monitored.

hair loss treatment regrowth hair loss

Clin Exp Dermatol. 2009;34:694

Pattern Hair loss and insulin resistance
Nabaie L, ET AL

Edited for Hair regrowth

Hair loss in androgenic alopecia is androgen-dependent. Insulin is found in hair follicles and may play a role in the regulation of androgen metabolism and the hair-regrowth cycle. To compare the insulin resistance between people with androgenic alopecia and a control group. A case-control study was conducted with 97 cases in the patient and 87 in the control group. Serum fasting insulin level, fasting blood glucose, serum total cholesterol, triglyceride and high-density lipoprotein (HDL) were all measured in both groups. There was no difference in serum fasting insulin level, fasting blood glucose, serum total cholesterol, triglyceride, HDL and insulin resistance between the two groups. Despite previous reports suggesting a link, our study found no significant relationship between insulin resistance and androgenic alopecia (hai rloss). Further studies are warranted.

Hair Loss Treatment at the Proctor Clinic

J Exp Med. 1924;40:517

THE PRODUCTION OF PERSISTENT HAIR LOSS IN RABBITS BY ROENTGEN RADIATION;
Clark H, Sturm E.

Seven areas on the abdomen of each of fourteen rabbits were exposed to soft Roentgen radiation of constant quality in doses varying, in the region of the value critical for the production of persistent hair loss (which did not regrow), by regular steps of about 4 per cent. Without exception the critical dose was found to lie between two such values, the upper limit being represented by exposures on eight of the animals and the lower on ten of them. With certain reservations, the critical dose corresponds to the production of 2.04 x 10(15) ions of either sign per gm. of tissue.

Edited for hair loss blog

J Invest Dermatol. 1976;67:98-105.

Hair.
Ebling FJ.

The psychologic importance of hair to man is in inverse ratio to its physical function. Except for scalp hair and desultory areas of sexual hair, most of man's hair follicles are vestigial. Three problems of hair regrowth remain to be solved: (1) how the intermittent activity of hair follicles in both animals and man is controlled; (2) how the male hormone alters the hair cycle in human skin; and (3) why larger hairs are produced by testosterone in some areas of the body when in some individuals the hair follicles in the scalp regress. Studies in which skin grafts from rats of different ages were exchanged showed that hair follicles are innately programmed but can be slowly influenced by systemic factors. Steroid hormones, especially estrogens, slow down the moult cycle whereas thyroid hormones accelerate it. What establishes the innate rhythm remains problematical. The fact that plucking out the club hair initiates activity in resting follicles has been explained by the hypothesis that the mitotic inhibitor which accumulates during anagen is normally used up or dispersed during telogen or by wounding. However, contrary to this theory, follicular activity is not prolonged by epilation during anagen. Moreover, if rats are epilated within one or two days of eruption, only club hairs are removed since forceps cannot grasp the tips of the new hairs. Such epilation does not affect the anagen in progress, but remarkedly enough the subsequent resting phase is shortened. Both sexual hair and male-pattern baldness depend on androgenic hormones. Target organs of testosterone convert the hormone to active metabolites, chiefly 5alpha-dihydrotestosterone. In skin, however, 5alpha-dihydrotestosterone may not be the only active tissue androgen. The major metabolite of testosterone incubated with hair roots in androstenedione, and hirsute women without other obvious endocrine abnormality sometimes excrete high levels of androstanediol. Both steroids stimulated the sebaceous glands of hypophysectomized-castrated rats, which, however, showed only a limited response to testosterone. The androgenic steroids, the enzymes that convert them to their active metabolites, and the proteins that bind them are undoubtedly very important to the problems of the growth of sexual hair and male-pattern baldness.